Andrographolide, Apoptosis Inducer

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Catalog numberSIH-220-500MG
NameAndrographolide, Apoptosis Inducer
Size500 mg
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Stock availabilitIn StockIn Stock
CAS number5508-58-7
DescriptionApoptosis Inducer
Molecular weight350,45 g/mol
Primary research fieldsCancer, Apoptosis
Other name(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
Product categorySmall Molecules
Product typeInducer
Chemical formulaC20H30O5
Purity pourcentage>98%
Soluble inDMSO
Physical appearanceOff-white Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem number5318517
Scientific contextAndrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement (2, 3).
Bibliography1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158.
Release date8-Apr-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Andrographolide (SIH-220), a Induces mitochondrial -mediated apoptosis in lymphoma cells. CAS #: 5508-58-7. Molecular Formula: C20H30O5. Molecular Weight: 350.45 g/mol. Chemical structure of Andrographolide, a Induces mitochondrial -mediated apoptosis in lymphoma cells (SIH-220). CAS # 5508-58-7. Molecular Formula: C20H30O5.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.5
Additional descriptionThis 1 is suited for programmed cell-death studies.