17-DMAG, Hsp90 inhibitor

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Catalog numberSIH-114A
Name17-DMAG, Hsp90 inhibitor
Size1 mg
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Stock availabilitIn StockIn Stock
CAS number30562-34-6
DescriptionHsp90 inhibitor
Molecular weight616,8 g/mol
Primary research fieldsCancer, Heat Shock
Other namenone
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC32H48N4O8
Purity pourcentage>98%
Soluble inSoluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Physical appearancePurple Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem number9852573
Scientific context17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
Bibliography1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077. 2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381. 3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 17-DMAG (SIH-114), a Hsp90 inhibitor. CAS #: 30562-34-6. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol. Chemical structure of 17-DMAG, a Hsp90 inhibitor (SIH-114). CAS # 30562-34-6. Molecular Formula: C32H48N4O8.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.001
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.