AG 1517, EGFR kinase inhibitor

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Catalog numberSIH-427-25MG
NameAG 1517, EGFR kinase inhibitor
Size25 mg
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Stock availabilitIn StockIn Stock
CAS number153436-54-5
DescriptionEGFR kinase inhibitor
Molecular weight360,2 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868, PD 153,035, SU 5271, 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC16H14BrN3O2
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO
Physical appearanceWhite to off-white solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Acute toxicity, Oral (Category 3) Skin irritation (Category 2) Serious eye damage (Category 1) Specific target organ toxicity-single exposure (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H315 Causes skin irritation. H318 Causes serious eye damage. H335 May cause respiratory irritation Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
PubChem number4705
Scientific contextAG 1517 is a potent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.
Bibliography1. Kunkel M.W., et al. (1996) Investigational New Drugs. 13(4): 295–302.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AG 1517 (SIH-427), a EGFR tyrosine kinase inhibitor. CAS #: 153436-54-5. Molecular Formula: C16H14BrN3O2. Molecular Weight: 360.2 g/mol. Chemical structure of AG 1517, a EGFR tyrosine kinase inhibitor (SIH-427). CAS # 153436-54-5. Molecular Formula: C16H14BrN3O2.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.