Brefeldin A, GEF inhibitor

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Catalog numberSIH-225-25MG
NameBrefeldin A, GEF inhibitor
Size25 mg
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Stock availabilitIn StockIn Stock
CAS number20350-15-6
DescriptionGEF inhibitor
Molecular weight280,36 g/mol
Primary research fieldsCancer, Apoptosis
Other nameCyanaein
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC16H24O4
Purity pourcentage>98%
Soluble inSoluble to 10 mM in ethanol and to 50 mM in DMSO
Physical appearanceWhite Crystalline Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310
PubChem number5287620
Scientific contextBrefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
Bibliography1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.
Release date8-Apr-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol. Chemical structure of Brefeldin A, a Inhibits intracellular transport (SIH-225). CAS # 20350-15-6. Molecular Formula: C16H24O4.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.