BIBW 2992, EGFR, HER2 kinase inhibitor

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Catalog numberSIH-496-5MG
NameBIBW 2992, EGFR, HER2 kinase inhibitor
Size5 mg
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Stock availabilitIn StockIn Stock
CAS number850140-72-6
DescriptionEGFR, HER2 kinase inhibitor
Molecular weight485,9 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameAfatinib, N-​[4-​[(3-​chloro-​4-​fluorophenyl)amino]-​7-​[[(3S)-​tetrahydro-​3-​furanyl]oxy]-​6-​quinazolinyl]-​4-​(dimethylamino)-​2-​butenamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC24H25ClFN5O3
Purity pourcentage>99%
Soluble inSoluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
Physical appearanceCrystalline solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Acute Toxicity: Oral, Category 2 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300: Fatal if swallowed. H315: Causes skin irritation. H318: Causes serious eye damage. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage through prolonged or repeated exposure. Precautionary statements: P264: Wash {hands} thoroughly after handling. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P302+352: IF ON SKIN: Wash with plenty of soap and water. P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.
PubChem number10184653
Scientific contextBIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.
Bibliography1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of BIBW 2992 (SIH-496), a EGFR and HER2 kinase inhibitor. CAS #: 439081-18-2. Molecular Formula: C24H25ClFN5O3. Molecular Weight: 485.9 g/mol. Chemical structure of BIBW 2992, a EGFR and HER2 kinase inhibitor (SIH-496). CAS # 439081-18-2. Molecular Formula: C24H25ClFN5O3.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.