AG490, JAK-2 kinase inhibitor

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Information

Catalog numberSIH-428-5MG
NameAG490, JAK-2 kinase inhibitor
Size5 mg
Price120.00EUR
SKU01012511926
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number133550-30-8
DescriptionJAK-2 kinase inhibitor
Molecular weight294,3 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameTyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC17H14N2O3
OriginSynthetic
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Physical appearanceTan solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Acute toxicity, Oral (Category 3), H301 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up.
PubChem number5328779
Scientific contextAG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Bibliography1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828. 3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol. Chemical structure of AG490, a JAK-2 kinase inhibitor (SIH-428). CAS # 133550-30-8. Molecular Formula: C17H14N2O3.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.