Amiodarone Hydrochloride, Autophagy inducer

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Information

Catalog numberSIH-393-1G
NameAmiodarone Hydrochloride, Autophagy inducer
Size1 g
Price130.00EUR
SKU01012511865
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number19774-82-4
DescriptionAutophagy inducer
Molecular weight681,77 g/mol
Primary research fieldsCancer, Autophagy
Other name2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Product categorySmall Molecules
Product typeInducer
Chemical formulaC25H29I2NO3•HCl
OriginSynthetic
Purity pourcentage>99 %
Soluble inSoluble to 50 mM in DMSO
Physical appearanceWhite solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303- May be harmful if swallowed. H312 + H332- Harmful in contact with skin or if inhaled Precautionary statements: P280- Wear protective gloves/ protective clothing.
PubChem number441325
Scientific contextAmiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
Bibliography1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53. 2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.
Release date31-Mar-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Amiodarone Hydrochloride (SIH-393), a Autophagy inducer. CAS #: 19774-82-4. Molecular Formula: C25H29I2NO3.HCl. Molecular Weight: 681.77 g/mol. Chemical structure of Amiodarone Hydrochloride, a Autophagy inducer (SIH-393). CAS # 19774-82-4. Molecular Formula: C25H29I2NO3.HCl.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)1