A-803467, NaV1.8 blocker

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Catalog numberSIH-304-10MG
NameA-803467, NaV1.8 blocker
Size10 mg
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Stock availabilitIn StockIn Stock
CAS number944261-79-4
DescriptionNaV1.8 blocker
Molecular weight357,79 g/mol
Primary research fieldsNeuroscience, Ion Channels, Sodium Channels
Other name5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC19H16ClNO4
Purity pourcentage>98%
Soluble inSoluble to 100 mM in DMSO and to 25 mM in ethanol
Physical appearanceBeige Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H3012
PubChem number16038374
Scientific contextA selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
Bibliography1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.
Release date8-Apr-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of A-803467 (SIH-304), a NaV1.8 blocker. CAS #: 944261-79-4. Molecular Formula: C19H16ClNO4. Molecular Weight: 357.79 g/mol. Chemical structure of A-803467, a NaV1.8 blocker (SIH-304). CAS # 944261-79-4. Molecular Formula: C19H16ClNO4.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.01