A-967079, TRPA1 blocker

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Information

Catalog numberSIH-301-50MG
NameA-967079, TRPA1 blocker
Size50 mg
Price491.00EUR
SKU01012511692
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number1170613-55-4
DescriptionTRPA1 blocker
Molecular weight207,3 g/mol
Primary research fieldsNeuroscience, Ion Channels, Transient Receptor Potential Channels
Other name(1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC12H14FNO
OriginSynthetic
Purity pourcentage>98%
Soluble inSoluble in DMSO (25 mg/ml)
Physical appearanceWhite solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
PubChem number42641861
Scientific contextA-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with>1000-fold selectivity over other TRP channels and>150-fold selectivity over 75 other tested proteins (2).
Bibliography1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172.
Release date16-May-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of A-967079 (SIH-301), a TRPA1 blocker. CAS #: 1170613-55-4. Molecular Formula: C12H14FNO. Molecular Weight: 207.3 g/mol. Chemical structure of A-967079, a TRPA1 blocker (SIH-301). CAS # 1170613-55-4. Molecular Formula: C12H14FNO.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05