Astemizole, Herg channel blocker

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Catalog numberSIH-302-50MG
NameAstemizole, Herg channel blocker
Size50 mg
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Stock availabilitIn StockIn Stock
CAS number68844-77-9
DescriptionHerg channel blocker
Molecular weight458,57 g/mol
Primary research fieldsNeuroscience, Ion Channels
Other name1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC28H31FN4O
Purity pourcentage>98%
Soluble inSoluble to 100 mM in DMSO and to 25 mM in ethanol
Physical appearanceWhite solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62 - Possible risk of impaired fertility Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
PubChem number2247
Scientific contextAstemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
Bibliography1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300. 2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.
Release date8-Apr-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol. Chemical structure of Astemizole, a Herg channel blocker (SIH-302). CAS # 68844-77-9. Molecular Formula: C28H31FN4O.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05