AS 041164 , PI 3-Kgamma kinase inhibitor

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Catalog numberSIH-433-10MG
NameAS 041164 , PI 3-Kgamma kinase inhibitor
Size10 mg
Price130.00EUR
SKU01012511931
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number6318-41-8
DescriptionPI 3-Kgamma kinase inhibitor
Molecular weight249,2 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameNSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC11H7NO4S
OriginSynthetic
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO (25 mg/ml). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle
Physical appearanceYellow solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number233033
Scientific contextAS 041164 is a selective PI 3-Kγ isoform inhibitor. It also blocks neutrophil migration.
Bibliography1. Ferrandi C., et al. (2007) J. Pharmacol. Exp.Ther. 322(3): 923–930.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AS 041164 (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol. Chemical structure of AS 041164 , a PI 3-Kgamma kinase inhibitor (SIH-433). CAS # 6318-41-8. Molecular Formula: C11H7NO4S.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.01
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.