Apigenin, Protein kinase inhibitor

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Catalog numberSIH-249-50MG
NameApigenin, Protein kinase inhibitor
Size50 mg
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Stock availabilitIn StockIn Stock
CAS number520-36-5
DescriptionProtein kinase inhibitor
Molecular weight270,2 g/mol
Primary research fieldsCancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC15H10O5
Purity pourcentage>98%
Soluble inSoluble to 50 mM in DMSO
Physical appearanceWhite Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68 - Possible risk of irreversible effects
PubChem number5280443
Scientific contextApigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).
Bibliography1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
Release date16-May-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Apigenin (SIH-249), a Protein kinase inhibitor. CAS #: 520-36-5. Molecular Formula: C15H10O5. Molecular Weight: 270.2 g/mol. Chemical structure of Apigenin, a Protein kinase inhibitor (SIH-249). CAS # 520-36-5. Molecular Formula: C15H10O5.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.