MPP+ iodide
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- SMILES: [I-].C[n+]1ccc(cc1)-c1ccccc1
- Formula: C12H12IN
- Purity: 0.9996
- CAS#: 36913-39-0
- Molecular Weight: 297.139
- Bioactivity: MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.