ERRα antagonist-1
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ERRα antagonist-1
- SMILES: N1=C(SCC1)N2C(=NC3C=4C=CC=CC4C=CC=5C=CC=CC53)SCC2
- Formula: C21H19N3S2
- Purity: 1
- CAS#: 1072145-33-5
- Molecular Weight: 377.52
- Bioactivity: ERRα antagonist-1 is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
For research use only.
