TNFAIP3 Antibody
€ Preis anfragen
Ask for price
TNFAIP3 Antibody: TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-α, inhibiting NF-κB-dependent gene expression, and protecting cells from TNF-α-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- Research area: Innate Immunity
- Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Homology: N/A
- Immunogen: TNFAIP3 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TNFAIP3.
- The immunogen is located within the last 50 amino acids of TNFAIP3.
- Tested Applications: E, WB, IHC-P, IF
- Applications: TNFAIP3 antibody can be used for detection of TNFAIP3 by Western blot at 1 μ
- g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ
- g/mL. For immunofluorescence start at 20 μ
- g/mL.
- Antibody validated: Western Blot in human samples
- Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
- Specificity: N/A
- Positive control 1: Cat. No. 1210 - HEK293 Cell Lysate
- Positive control 2: Cat. No. 10-101 - Human Lung Tissue Slide
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: N/A
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: TNFAIP3 Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: TNFAIP3 Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: Tnfaip3
- Accession #: Q60769
- Protein GI #: 2498097
- NCBI gene ID#: 21929
- NCBI official full name: tumor necrosis factor, alpha-induced protein 3
- NCBI organism: Mus musculus
- SWISSPROT #: Q60769
- TNFAIP3 antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Optimal dilutions for each application to be determined by the researcher.
