PDL2 Detection Set (Risk Free)
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Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through an alternative receptor from PD-1.ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications
Optimal dilutions for each application to be determined by the researcher.
- Host Species: Mouse
- Species Reactivity: Human
- Homology: N/A
- Immunogen: Mouse monoclonal PD-L2 antibodies were raised against the extracellular domain of human PD-L2.
- Tested Applications: E, WB, ICC, IHC-P, Flow, IF
- Applications: N/A
- Specificity: N/A
- Purification: Antibodies are supplied as protein A purified IgG1.
- Clonality: Monoclonal
- Isotype: IgG1
- Conjugate: Unconjugated
- Physical State: Liquid
- Buffer: PBS containing 0.02% sodium azide.
- Concentration: Antibody 1 mg/mL
- Set Contents: PD-L2 Antibody [4E10], Cat. No. RF16021 (20 µg). PD-L2 Antibody [8C12], Cat. No. RF16022 (20 µg). PD-L2 Antibody [7C7], Cat. No. RF16023 (20 µg). PD-L2 Antibody [7C1], Cat. No. RF16024 (20 µg). PD-L2 Antibody [10H4], Cat. No. RF16025 (20 µg)
- Products: RF16021, RF16022, RF16023, RF16024, RF16025
- Antibodies can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping Condition: Not Specified
For Research Use Only