PD1 Antibody [7H6] (biotin)
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Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- Research area: Immunology
- Host species: Mouse
- Species reactivity: Human
- Homology: N/A
- Immunogen: PD-1 antibody (biotin) was raised against the extracellular domain of human PD-1.
- Tested Applications: E
- Applications: PD1 antibody can be used for as detection antibody in Sandwich Elisa at 1 μ
- g/mL.
- Specificity: N/A
- Positive control 1: Cat. No. 1306 - Human Spleen Tissue Lysate
- Positive control 2: Cat. No. 1315 - Human Tonsil Tissue Lysate
- Positive control 3: Cat. No. 1369 - Human Lymph node Tissue Lysate
- Positive control 4: Cat. No. 10-901 - Human Spleen Tissue Slide
- Positive control 5: Cat. No. 10-001 - Human Breast Tissue Slide
- Positive control 6: Cat. No. 17-010 - HEK293 Cell Slide
- Predicted molecular weight: N/A
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: PD-1 Antibody (biotin) is supplied as protein A purified IgG1.
- Clonality: Monoclonal
- Clone: 7H6
- Isotype: IgG1
- Conjugate: biotin
- Physical state: Liquid
- Buffer: PD-1 Antibody (biotin) is supplied in PBS containing 1% BSA and 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: PDCD1
- Accession #: NP_005009
- Protein GI #: 145559515
- NCBI gene ID#: 5133
- NCBI official full name: programmed cell death 1
- NCBI organism: Homo sapiens
- SWISSPROT #: Q15116
- PD-1 Antibody (biotin) can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Optimal dilutions for each application to be determined by the researcher.
