EGF R Recombinant Protein
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The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
- Tested Applications: E, WB
- Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.5kDa. The protein migrates as 110-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Predicted Molecular Weight: 70.5kDa
- Physical state: Lyophilized
- Buffer: PBS, pH7.4
- Concentration: N/A
- NCBI official symbol: EGFR
- Accession #: NP_005219.2
- Protein GI: N/A
- NCBI gene ID#: 1956
- NCBI official full name: epidermal growth factor receptor
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P00533
- Background Reference 1: Herbst RS., 2004, Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl): 21–6.
- Background Reference 2: Giaccone, G., 2005, Ann. Onc. 16: 538-548.
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Human
- By Source: Human Cells
- By Species: Human
- Fusion tag: His Tag
- Sequence: Leu 25 - Ser 645
- Biology activity: N/A
- Purity: >95% as determined by SDS-PAGE.
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
