ACE-2 Recombinant Protein
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Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family which includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, heart, colon, small intestine and ovary at moderate levels. ACE2 is not inhibited by the classical ACE inhibitors, captopril and lisinopril and may play an important role in regulating the heart function.
- Tested Applications: N/A
- Applications: N/A
- Predicted Molecular Weight: Mol Mass: 84.63kD
- AP Mol Mass: 103kD
- Physical state: Liquid
- Buffer: 20mM Tris, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
- Concentration: batch dependent
- NCBI official symbol: ACE2
- Accession #: Q9BYF1
- Protein GI: N/A
- NCBI gene ID#: 59272
- NCBI official full name: angiotensin-converting enzyme 2
- NCBI organism: Homo sapiens
- Peptide sequence: Gln18-Ser740
- SWISSPROT #: N/A
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Human
- By Source: Human Cells
- By Species: Other
- Fusion tag: His Tag
- Sequence: Gln18-Ser740
- Biology activity: Human ACE2 protein can bind with SARS-CoV-2 Spike protein (RBD) in functional ELISA assay.
- Purity: >95% as determined by reducing SDS-PAGE.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.