Trametinib
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Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].
- CAS number: 871700-17-3
- Purity: 99.59
- Formula: C26H23FIN5O4
- Solubility: DMSO : 25 mg/mL (ultrasonic
- warming
- heat to 60°C)
- SMILES: CC(NC1=CC=CC(N(C2=O)C(C(C(N2C3CC3)=O)=C(N4C)NC5=CC=C(C=C5F)I)=C(C4=O)C)=C1)=O
- Molecular Weight: 615.39
- Applications: Cancer-Kinase/protease
- -20°C, 3 years
- 4°C, 2 years (Powder)
