ERRα antagonist-1
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ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].
- CAS number: 1072145-33-5
- Purity: 98.48
- Formula: C21H19N3S2
- Solubility: DMSO : 25 mg/mL (ultrasonic
- warming
- heat to 60°C)
- SMILES: C12=CC=CC=C1C(/N=C3SCCN\3C4=NCCS4)C5=CC=CC=C5C=C2
- Molecular Weight: 377.53
- Applications: Neuroscience-Neuromodulation
4°C (Powder, protect from light)
