Anti-Hu CD24 APC

Der Lieferant: Gentaur

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166.10 EUR

Katalognummer: 270-1A-503-T100

Größe: 100 tests

Anti-Hu CD24 APC
Anti-Hu CD24 APC

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Anti-Hu CD24 APC
Anti-Hu CD24 APC

Katalognummer: / Größe: / Preis: EUR (Excluding VAT)

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  • CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4
  • it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
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